Skip to Main Content

++

Most forms of acute head injury increase the volume of the intracranial contents. Cerebral edema, hemorrhage, acute hydrocephalus, or rapidly growing tumors all result in intracranial hypertension (see Chapter 104 and Table 104-5). The relationship between the volume increase and the rise in intracranial pressure is not linear. Small volumes can be accommodated either by stretch, if the cranial sutures are still open, or by displacement of cerebrospinal fluid (CSF) into the spinal canal (this is why in most forms of intracranial hypertension, with the notable exception of hydrocephalus, the ventricles appear small). To a lesser extent, the blood contained at any time in the cerebral vessels, especially the cerebral veins, diminishes. As the volume increase produced by the injury becomes larger, however, the pressure increases more rapidly, a circumstance that can be described as a volume-dependent decrease in the compliance of the cranium. Any additional volume causes a disproportionate elevation in intracranial pressure.

++

The most immediate and dangerous consequence of increased intracranial pressure is a reduction in cerebral blood flow. Cerebral herniation (see Chapter 104) tends to be a later development. In most organs, blood flow is directly proportional to the difference between arterial and venous pressure (the perfusion pressure) and is inversely proportional to the resistance of the organ’s vascular bed. Some organs, such as the heart and the brain, regulate their vascular tone (and thus their vascular resistance) to maintain constant blood flow over a wide range of perfusion pressures appropriate for age (autoregulation). Below or above this autoregulation range, blood flow changes in proportion to perfusion pressure. (Other organs, such as the intestine and the skin, have their flow regulated by neural and humoral inputs in response to a variety of physiological circumstances, sometimes without change in blood pressure.)

++

The cranial enclosure introduces a new variable for consideration. The outside surface of the cerebral blood vessels is exposed to intracranial pressure. If this pressure exceeds venous pressure, then the effective perfusion pressure is the difference between arterial and intracranial pressure, the venous pressure becoming irrelevant in defining blood flow (just as the height of a waterfall is irrelevant in determining the flow of the river). Intracranial hypertension can reduce cerebral perfusion pressure below the autoregulation range of the cerebral blood vessels, resulting in cerebral ischemia.

++

Cerebrospinal fluid production and subsequent absorption is, like cerebral blood flow, quite dynamic. The choroid plexus accounts for at least 70% of the brain’s production of cerebrospinal fluid, and the transependymal movement of fluid from the brain parenchyma to the ventricular system accounts for the rest. The average volume of cerebrospinal fluid in children ages 4 to 13 years is 90 mL, and the rate of formation is approximately 500 mL per day, resulting in an hourly turnover of about 14% of the total volume.

++

The rate of production remains fairly constant and declines only slightly with increased intracranial pressure, but the rate of ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPediatrics Full Site: One-Year Subscription

Connect to the full suite of AccessPediatrics content and resources including 20+ textbooks such as Rudolph’s Pediatrics and The Pediatric Practice series, high-quality procedural videos, images, and animations, interactive board review, an integrated pediatric drug database, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPediatrics

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.