Skip to Main Content

++

Historically classified as group D streptococci, enterococci are now classified as a separate genus with at least 35 different species.

++

Epidemiology

++

Only two species, Enterococcus faecalis and Enterococcus faecium, account for all but a rare case of human disease. E faecalis is responsible for about 80% to 90% of human cases, but several studies show a rising proportion of cases due to E faecium. Enterococci are facultatively anaerobic oxidase- and catalase-positive gram-positive cocci that normally inhabit the bowel Approximately half of newborn infants have acquired colonization with enterococci by 1 week of age. These very hardy organisms grow at temperatures of 10°C to 60°C (50°F–140˚F) and remain viable for weeks on environmental surfaces such as bed rails, sinks, faucets, and doorknobs. Human-to-human spread is common in hospital settings.

++

Enterococci are generally not highly invasive pathogens and are typically classified as opportunists. They lack not only the major exotoxins and endotoxins associated with virulent streptococci and staphylococci, but also the enzymes that enable rapid tissue spread. Infections are most often associated with prolonged hospitalization particularly in intensive care or hematology/oncology units; use of broad-spectrum antibiotics; indwelling lines; immunocompromised state; or loss of integrity of the gastrointestinal tract, urinary tract, or skin.1

++

Clinical Manifestations

++

The three most common types of infection associated with enterococci are urinary tract infection (UTI), polymicrobial abdominal infections, and bacteremia or sepsis. Although infrequent, cases of focal organ infection, such as endocarditis, meningitis, and wound infections, may be severe. UTI caused by enterococci almost never occurs in otherwise healthy children. They are most often associated with indwelling urinary catheters and account for approximately 15% of nosocomial UTIs in children. Anatomic urinary tract anomalies, particularly vesicoureteral reflux, are more common in community-acquired enterococcal UTIs than those associated with gram-negative Enterobacteriaceae.2

++

Enterococci may be involved in intra-abdominal polymicrobial infections following intestinal perforation such as ruptured appendix or necrotizing enterocolitis. Although there has been controversy regarding the pathogenic role of enterococci in such infections, most authorities recommend adding an antibiotic to cover for enterococci in such infections.3 Enterococcal bacteremia or sepsis in children may not be identified with a specific focus, but common risk factors are use of broad-spectrum antibiotics or intravascular catheters in association with underlying conditions such as surgery, immunosuppression, transplants, or major organ dysfunction.4 Bacteremia without a focal infection may result in a self-limited illness or a severe and life-threatening illness, particularly in newborns or children with underlying disease. Bacteremia is often polymicrobial with other enteric microorganisms. Mortality occurs in up to 25% of cases, but is hard to separate from the underlying health problems.

++

In newborns, infection may present as early onset sepsis in the first several days of life, similar to early onset group B streptococcal sepsis. However, most neonatal enterococcal infections are nosocomial and occur after the second week of life, typically in ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPediatrics Full Site: One-Year Subscription

Connect to the full suite of AccessPediatrics content and resources including 20+ textbooks such as Rudolph’s Pediatrics and The Pediatric Practice series, high-quality procedural videos, images, and animations, interactive board review, an integrated pediatric drug database, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPediatrics

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.