Skip to Main Content

++

Drug-Induced Liver Injury

++

Adverse drug reactions in children are uncommon. Nevertheless, drug-induced hepatotoxicity, when it occurs, must be promptly recognized, and the offending agent discontinued, although cessation does not always result in rapid recovery. Delays in recognizing hepatic injury may significantly contribute to morbidity, resulting in a need for liver transplantation or in death.1-5

++

The role of the liver in the processing or biotransformation of xenobiotics (foreign substances) is discussed in Chapter 418. Mechanisms of hepatoxicity vary, as they depend on the drug, dosage, and patient factors such as age, gender, nutrition, and genetic predisposition. In general, medicinal and environmental agents known to cause hepatotoxicity have been characterized as predictable (intrinsic) or unpredictable (idiosyncratic) hepatotoxins. The patterns of liver injuries are clinically and histopathologically diverse (Table 422-1).

++
Table Graphic Jump Location
Table 422-1. Clinical and Pathologic Findings in Drug-Induced Liver Disease in Children 

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPediatrics Full Site: One-Year Subscription

Connect to the full suite of AccessPediatrics content and resources including 20+ textbooks such as Rudolph’s Pediatrics and The Pediatric Practice series, high-quality procedural videos, images, and animations, interactive board review, an integrated pediatric drug database, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPediatrics

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.