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Hydrocephalus is a condition in which there is an accumulation of cerebrospinal fluid (CSF) within the ventricles, leading to increased intracranial pressure. Hydrocephalus may be caused by increased production, decreased absorption, or obstruction to flow of CSF. By contrast, ventricular dilatation due to loss of brain tissue or atrophy is not considered to be hydrocephalus.


Cerebrospinal Fluid Dynamics


Typically, cerebrospinal fluid (CSF) is produced at a volume of 20 mL/hour, or more than 500 mL per day, in the adult. Total CSF volume in infants is approximately 50 mL, as compared to approximately 150 mL in normal adults. Cerebrospinal fluid is produced by active secretion and diffusion predominantly in the choroid plexus, located in the lateral ventricles and the roof of the fourth ventricle. Cerebrospinal fluid passes from the lateral ventricles into the paired foramina of Monro to reach the third ventricle and then along the cerebral aqueduct into the fourth ventricle. Once in the fourth ventricle, CSF flows through the midline foramen of Magendie or laterally through the paired foramina of Luschka into focally enlarged areas of subarachnoid space known as the basal cisterns, which connect the spinal and intracranial subarachnoid spaces (Fig. 553-1). Cerebrospinal fluid is in continual flow around the brain and spinal cord and within the ventricles in a cephalad direction. Production of CSF is regulated by the enzyme carbonic anhydrase, and reabsorption occurs within the arachnoid villi in the meninges into the venous channels of the sagittal sinus. Smaller amounts of CSF absorption also occurs across the ependymal lining of the ventricles. Typically, there is a delicate balance between CSF production and reabsorption; hydrocephalus results when that balance is disrupted. However, CSF production rarely fluctuates in normal circumstances and even in the face of rising intracranial pressure, unless extremely elevated pressures are reached.

Figure 553-1.
Graphic Jump Location

Schematic diagram of a sagittal section of the brain with arrows that trace the flow of cerebrospinal fluid. Cerebrospinal fluid flows out of the ventricular system through the fourth ventricle outlets into the basal cisterns, and then through the tentorium over the cerebral hemispheres toward the arachnoid granulations in the superior sagittal sinus. There is bidirectional flow of CSF in the spinal canal. A, lateral ventricle; B, subarachnoid space; C, cerebellum; D, foramen of Magendie; E, aqueduct of Sylvius; F, third ventricle; G, foramen of Monro.


Potential Etiologies


Hydrocephalus is generally classified as communicating, obstructive, and external, depending on the underlying etiology.1 Communicating hydrocephalus refers to a situation in which cerebrospinal fluid (CSF) flows freely into the subarachnoid space, but the total volume of CSF is increased secondary to either impaired reabsorption or overproduction. Impaired reuptake of CSF may result from blood within the ventricular system (as occurs with subarachnoid hemorrhage) increased protein content (resulting from meningitis) or an increased cell content from malignant ...

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