TY - CHAP M1 - Book, Section TI - Acquired Coagulation Disorders A1 - Jaffray, Julie A1 - Ko, Richard A1 - Young, Guy A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Many hemorrhagic disorders in children are caused by genetic defects, but there exist a number of important acquired conditions that can lead to abnormal coagulation and subsequent bleeding complications. These conditions occur in disparate clinical situations ranging from otherwise healthy-appearing neonates to critically ill children with multiorgan failure. The most important of these conditions are hemorrhagic disorders that result from vitamin K deficiency, liver failure, or disseminated intravascular coagulation (a condition that can lead to both bleeding and thrombosis). Other conditions include acquired platelet dysfunction (see Chapter 435), coagulopathies of hypothermia and extracorporeal life support, and acquired inhibitors to specific coagulation proteins. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182910208 ER -