TY - CHAP M1 - Book, Section TI - Systemic Lupus Erythematosus A1 - Lo, Mindy S. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Systemic lupus erythematosus (SLE) is a chronic, potentially serious systemic autoimmune disease. It is characterized biochemically by the presence of autoantibodies; in particular, antibodies directed against nuclear antigens. SLE is a heterogeneous disease in that clinical manifestations can vary significantly from patient to patient, ranging from mild presentations to severe organ dysfunction. Morbidity and mortality rates have improved dramatically over the past few decades due to advances in therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146122655 ER -