TY  - CHAP
M1  - Book, Section
TI  - Chapter 446. Clinical Trials in Pediatric Oncology
A1  - Smith, Malcolm A.
A1  - Reaman, Gregory H.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - Clinical  trials  have  played  a  central  role  in  converting  many  of  the  once  fatal  childhood  cancers  into  conditions  in  which  the  vast  majority  of  children  with  these  diagnoses  can  be  cured.  For  example,  much  of  the  progress  in  improving  survival  rates  for  children  with  acute  lymphoblastic  leukemia  (ALL)  can  be  attributed  to  the  conduct  of  sequential  phase  III  clinical  trials  in  which  more  effective  treatment  approaches  for  children  with  ALL  were  reliably  identified  and  carried  forward  as  the  standard  of  care  that  replaced  less  effective  therapies.  The  end  result  of  these  series  of  clinical  trials  conducted  over  more  than  four  decades  has  been  the  identification  of  treatments  that  produce  much  higher  5-year  survival  rates  than  those  previously  achieved  (Fig.  446-1).  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7041915
ER  -