TY  - CHAP
M1  - Book, Section
TI  - Management of Conjugated Hyperbilirubinemia (Neonatal Cholestasis)
A1  - Bhutani, Vinod K.
A2  - Stevenson, David K.
A2  - Cohen, Ronald S.
A2  - Sunshine, Philip
PY  - 2015
T2  - Neonatology: Clinical Practice and Procedures
AB  - Jaundice  that  persists  or  recurs  during  the  second  week  of  life  requires  inquiry.  Frequently,  such  jaundice  is  caused  by  elevation  of  the  unconjugated,  or  indirect,  bilirubin  and  is  often  the  result  of  a  benign  process.  More  concerning  is  jaundice  caused  by  elevation  of  the  conjugated  bilirubin  fraction.  Neonatal  cholestasis  is  caused  by  an  accumulation  of  biliary  substances,  such  as  bilirubin  and  bile  acids,  because  of  impaired  canalicular  bile  flow.  Manifestations  of  conjugated  hyperbilirubinemia  must  be  differentiated  from  unconjugated  hyperbilirubinemia  because  it  is  more  often  associated  with  a  specific  disease  process  (Figure  98-1).  The  medical  management  of  cholestasis  is  largely  supportive  because  the  underlying  disease  is  often  untreatable  medically.  Such  treatment  addresses  complications  of  chronic  cholestasis  rather  than  the  underlying  cause.  These  complications  include  malabsorption,  nutritional  deficiencies,  and  pruritus.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1109798933
ER  -