TY  - CHAP
M1  - Book, Section
TI  - Renal Tubular Disorders
A1  - Baum, Michel
A2  - Kline, Mark W.
Y1  - 2018
N1  - 
T2  - Rudolph's Pediatrics, 23e
AB  - There  are  approximately  1  million  glomeruli  in  each  kidney,  which  filter  blood  and  generate  an  ultrafiltrate  of  plasma.  With  a  glomerular  filtration  rate  of  120  mL/min/1.73  m2,  the  kidneys  of  an  adult  generate  approximately  170  L  of  an  ultrafiltrate  of  plasma  daily,  which  is  delivered  to  the  renal  tubules.  The  renal  tubules  reabsorb  organic  solutes,  salts,  and  water  to  maintain  a  constant  extracellular  fluid  volume  and  composition.  In  addition,  organic  anions  and  cations,  which  are  protein  bound  and  not  filtered  by  the  glomerulus,  are  secreted  by  the  proximal  tubule.  The  final  urine  contains  about  one  hundredth  of  the  volume  and  sodium  as  that  in  the  original  glomerular  filtrate,  but  contains  waste  products.  There  are  12  nephron  segments,  which  have  different  transport  properties  to  perform  the  task  of  modifying  the  glomerular  ultrafiltrate  so  that  we  maintain  a  constant  volume  and  composition  of  the  extracellular  fluid.  Disorders  of  tubular  function  can  be  due  to  inherited  defects  in  transporters,  result  from  mutations  in  factors  that  regulate  transport,  or  result  from  inherited  or  acquired  disorders  that  cause  tubular  injury.  Renal  transport  disorders  can  be  mild,  with  little  or  no  clinical  consequences,  or  life-threatening  depending  on  the  transporters  and  nephron  segments  affected.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1182912852
ER  -