TY - CHAP M1 - Book, Section TI - Chapter 420. Autoimmune Disorders of the Liver A1 - Yazigi, Nada A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. Y1 - 2011 N1 - T2 - Rudolph's Pediatrics, 22e AB - Autoimmune liver disorders result from a spectrum of immune dysregulation where the liver can be the only organ affected or may be part of a systemic multiorgan disorder with the inflammatory response being mediated by systemic or locally produced (portal system) cytokines. The immunogenic target varies and may include the liver parenchyma, bile duct epithelium or vasculature, with “overlap” syndromes that include both biliary and parenchymal involvement being increasingly recognized among children. Clinical manifestations vary depending upon the pattern of involvement. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/23 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7038605 ER -