TY  - CHAP
M1  - Book, Section
TI  - Diabetes Insipidus (DI)
A1  - Hay, Jr, William W.
A1  - Levin, Myron J.
A1  - Deterding, Robin R.
A1  - Abzug, Mark J.
PY  - 2017
T2  - Quick Medical Diagnosis & Treatment Pediatrics
AB  - Central  DI  is  an  inability  to  synthesize  and  release  vasopressinWithout  vasopressin,  the  kidneys  cannot  concentrate  urine,  causing  excessive  urinary  water  lossMost  common  causesMidline  defects  (septo-optic  dysplasia,  holoprosencephaly)Trauma  (surgery,  injury)Infiltrative/neoplastic  disease  (tumors  such  as  craniopharyngioma,  germinoma,  Langerhans  cell  histiocytosis,  sarcoidosis)Infectious  (meningitis)IdiopathicTraumatic  DI  often  has  three  phasesInitially  caused  by  edema  in  the  hypothalamus  or  pituitary  areaIn  2–5  days,  unregulated  release  of  vasopressin  from  dying  neurons  causes  the  syndrome  of  inappropriate  secretion  of  antidiuretic  hormone  (SIADH)Finally,  permanent  DI  occurs  if  a  sufficient  number  of  vasopressin  neurons  are  destroyedOf  note,  germinomas  often  present  with  DI,  whereas  DI  in  craniopharyngioma  is  more  often  the  result  of  neurosurgical  intervention  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1145455068
ER  -