TY  - CHAP
M1  - Book, Section
TI  - Chapter 363. Neoplastic and Proliferative Disorders
A1  - Barrio, Victoria R.
A1  - Eichenfield, Lawrence F.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - Dermatofibromas  (fibrous  histiocytomas)  are  red-to-brown,  firm  nodules,  ranging  in  diameter  from  a  few  millimeters  to  2  centimeters.  These  benign  lesions  are  often  located  on  the  lower  extremities  and  tend  to  persist  indefinitely.  Lateral  pressure  on  the  lesion  produces  dimpling  of  its  surface.1  Larger  lesions  may  be  concerning  for  dermatofibrosarcomaprotuberans,  which  is  a  rare,  more  invasive  lesion.  Biopsy  is  diagnostic  in  both  cases  and  may  be  necessary  to  distinguish  the  lesions.  Biopsy  of  a  dermatofibroma  reveals  prominent  fibrocytes  and  coarse  bundles  of  collagen  in  a  haphazard  fashion,  frequently  arranged  in  short  fascicles  that  interweave  (“storiform  pattern”).  There  is  often  hyperplasia  and  hyperpigmentation  of  the  overlying  epidermis.2Dermatofibrosarcoma  protuberans  is  usually  located  on  the  trunk,  often  has  a  blue  hue,  and  may  be  mistaken  for  a  vascular  lesion.3  It  is  locally  invasive  and  may  only  rarely  metastasize.  Wide  local  excision  or  Mohs  surgery  is  indicated,  and  preoperative  MRI  may  help  delineate  the  extent  of  the  lesion  before  surgery.4  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7033284
ER  -