RT Book, Section A1 Fung, Irene A1 Solrun Melkorka Maggadottir, A1 Brown-Whitehorn, Terri A2 Shah, Samir S. A2 Zaoutis, Lisa B. A2 Catallozzi, Marina A2 Frank, Gary SR Print(0) ID 1122459018 T1 Allergy and Asthma T2 The Philadelphia Guide: Inpatient Pediatrics, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071829212 LK accesspediatrics.mhmedical.com/content.aspx?aid=1122459018 RD 2024/04/18 AB Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction. It is most commonly triggered by interaction of an allergen with specific IgE antibody bound to mast cells and basophils leading to cell activation and mediator release. Non-IgE-mediated direct mast cell degranulation results in mediator release.