RT Book, Section
A1 Soriano-Guillén, Leandro
A1 Sarafoglou, Kyriakie
A1 Argente, Jesús
A2 Sarafoglou, Kyriakie
A2 Hoffmann, Georg F.
A2 Roth, Karl S.
SR Print(0)
ID 1140320372
T1 Precocious Puberty
T2 Pediatric Endocrinology and Inborn Errors of Metabolism, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071773140
LK accesspediatrics.mhmedical.com/content.aspx?aid=1140320372
RD 2024/04/19
AB Normal  pubertal  development  is  dependent  on  a  change  in  the  activity  of  the  hypothalamic-pituitary-gonadal  (HPG)  axis  from  a  period  of  relative  quiescence  during  childhood  to  its  reactivation  during  puberty.  Any  disruption  to  the  normal  inhibition  of  this  axis  during  childhood  results  in  central  precocious  puberty.  Alternatively,  secretion  of  or  exposure  to  sex  steroids  independent  of  this  axis  can  result  in  a  peripheral  form  of  precocious  puberty.  The  challenge  to  the  practitioner  is  to  identify  children  with  pathologic  forms  of  precocious  puberty  and  determine  whether  the  etiology  is  central  (gonadotropin-releasing  hormone  [GnRH]-dependent)  or  peripheral  (GnRH-independent)  in  order  to  initiate  appropriate  therapy.