RT Book, Section
A1 Knapp, Katherine M.
A2 Kline, Mark W.
SR Print(0)
ID 1182937165
T1 Candida
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182937165
RD 2024/04/24
AB Candida  species  are  yeast  forms  that  are  ubiquitous  in  nature  and  frequent  colonizers  of  human  skin  and  mucous  membranes  of  the  gastrointestinal,  respiratory,  and  female  genital  tracts.  Candida  species  are  the  most  common  cause  of  human  fungal  infections,  although  they  rarely  cause  invasive  disease  in  the  absence  of  mucosal  barrier  disruption  or  compromised  immune  systems.  Only  a  small  number  of  the  more  than  150  species  of  Candida  that  have  been  described  are  considered  to  be  pathogenic.  There  are  at  least  15  Candida  species  associated  with  human  disease,  but  most  invasive  infections  are  due  to  5  pathogens:  C  albicans,  C  glabrata,  C  tropicalis,  C  parapsilosis,  and  C  krusei.  Historically,  C  albicans  has  accounted  for  the  majority  of  invasive  infections,  but  in  more  recent  reports,  non-albicans  species  have  been  isolated  in  half  or  more  of  the  cases.  In  addition,  the  incidence  of  infections  due  to  C  albicans  isolates  that  are  resistant  to  azole  antifungals  is  increasing.  This  changing  epidemiology  has  implications  for  appropriate  treatment  of  antifungal-resistant  Candida  infections.