RT Book, Section
A1 Jaffray, Julie
A1 Ko, Richard
A1 Young, Guy
A2 Kline, Mark W.
SR Print(0)
ID 1182910208
T1 Acquired Coagulation Disorders
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182910208
RD 2024/04/19
AB Many  hemorrhagic  disorders  in  children  are  caused  by  genetic  defects,  but  there  exist  a  number  of  important  acquired  conditions  that  can  lead  to  abnormal  coagulation  and  subsequent  bleeding  complications.  These  conditions  occur  in  disparate  clinical  situations  ranging  from  otherwise  healthy-appearing  neonates  to  critically  ill  children  with  multiorgan  failure.  The  most  important  of  these  conditions  are  hemorrhagic  disorders  that  result  from  vitamin  K  deficiency,  liver  failure,  or  disseminated  intravascular  coagulation  (a  condition  that  can  lead  to  both  bleeding  and  thrombosis).  Other  conditions  include  acquired  platelet  dysfunction  (see  Chapter  435),  coagulopathies  of  hypothermia  and  extracorporeal  life  support,  and  acquired  inhibitors  to  specific  coagulation  proteins.