RT Book, Section
A1 Grompe, Markus
A2 Kline, Mark W.
SR Print(0)
ID 1182928289
T1 Disorders of Tyrosine Metabolism
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182928289
RD 2024/04/19
AB The  tyrosine  degradation  pathway  consists  of  5  enzymes,  and  inherited  disorders  have  been  described  for  4  of  these.  Importantly,  not  all  defects  are  characterized  by  hypertyrosinemia,  and  disease  pathologies  are  not  all  caused  by  elevated  tyrosine  levels.  Furthermore,  hypertyrosinemia  is  not  specific  for  disorders  of  the  tyrosine  degradation  pathway.  It  can  also  be  found  in  other  conditions  such  as  transient  tyrosinemia  of  the  preterm  newborn,  scurvy,  and  many  diseases  that  cause  hepatocellular  injury.