RT Book, Section A1 Bhatt, Amit A1 Coats, David K. A2 Kline, Mark W. SR Print(0) ID 1182927028 T1 Retinopathy of Prematurity T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182927028 RD 2024/04/20 AB Retinopathy of prematurity (ROP) is a disorder that affects the developing retinal blood vessels of premature infants. It is the leading cause of both acquired and preventable childhood blindness in the United States. The disease was first recognized in the 1940s and was initially thought to be due to the normal primitive vascular system in the vitreous cavity persisting in an abnormal fibrotic state. By 1952, ROP became recognized as an acquired disease, and in 1955, the role of excessive supplementary oxygen for premature infants was proven to be a significant causative factor. Despite many improvements in neonatal care practices, ROP continues into the 21st century as a major complication of premature birth.