RT Book, Section
A1 Wenderfer, Scott E.
A1 Eddy, Allison A.
A2 Kline, Mark W.
SR Print(0)
ID 1182912708
T1 Glomerular Diseases
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182912708
RD 2024/04/20
AB Glomerular  diseases  present  clinically  in  several  different  ways  depending  on  the  nature  and  severity  of  the  primary  disease  and  the  extent  to  which  the  normal  physiologic  functions  of  the  glomerulus  are  perturbed.  Some  children  with  glomerulopathies  are  found  incidentally  to  have  microscopic  hematuria  or  proteinuria  but  are  otherwise  asymptomatic.  At  the  other  extreme,  children  may  become  critically  ill  with  oligoanuric  rapidly  progressive  glomerulopathy  in  need  of  urgent  dialysis.  Whereas  numerous  glomerular  diseases  are  inherited  (see  Chapter  469),  most  forms  are  acquired  and  are  generally  considered  to  be  immunologically  mediated.  There  are  3  classical  clinical  syndromes  that  develop  from  glomerular  injury:  acute  and  chronic  glomerulonephritis  (GN),  defined  by  the  triad  of  hematuria,  hypertension,  and  acute  kidney  injury  (AKI);  nephrotic  syndrome  (NS),  defined  by  proteinuria  and  hypoalbuminemia;  and  hemolytic-uremic  syndrome  (HUS),  defined  by  microangiopathic  hemolytic  anemia,  thrombocytopenia,  and  AKI.