RT Book, Section
A1 Schleiss, Mark R.
A1 Smith, Arnold L.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7025809
T1 Chapter 263. Haemophilus Influenzae
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7025809
RD 2024/04/23
AB Although  the  types  of  infectious  diseases  caused  by  Haemophilus  influenzae  have  changed  considerably  in  recent  years  as  a  result  of  the  widespread  implementation  of  routine  childhood  immunization  against  type  b  organisms,  this  organism  remains  an  important  pathogen.  There  are  two  major  categories  of  H  influenzae:  unencapsulated  strains  (untypeable,  NTHi)  and  encapsulated  strains  (typeable).  The  unencapsulated  strains  are  responsible  chiefly  for  infections  at  mucosal  surfaces,  including  conjunctivitis,  otitis  media,  sinusitis,  and  bronchitis.  In  contrast,  one  of  the  six  antigenically  distinct  encapsulated  strains,  strain  type  b,  is  associated  with  most  invasive  diseases  such  as  septicemia,  meningitis,  cellulitis,  septic  arthritis,  epiglottitis,  and  pneumonia.  Prior  to  the  availability  of  an  effective  vaccine,  H  influenzae  type  b  (Hib)  was  the  most  common  cause  of  pediatric  bacterial  meningitis  in  the  United  States.