RT Book, Section
A1 Nobile, Donna M.
A1 Kleiman, Martin B.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7029161
T1 Chapter 303. Sporotrichosis
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7029161
RD 2024/04/25
AB Sporotrichosis  is  an  uncommon,  chronic  mycosis  caused  by  Sporothrix  schenckii.  This  ubiquitous  plant  saprophyte  is  a  dimorphic  fungus  that  grows  as  a  mold  at  room  temperature  and  as  a  yeastlike  form  in  tissue.  Although  distributed  worldwide,  it  is  found  most  commonly  in  warm,  highly  humid  regions  and  in  temperate  climates.  Mexico,  other  parts  of  Central  America,  Asia,  the  United  States,  Canada,  and  France  are  endemic  areas.  Infection  is  characterized  by  isolated  cutaneous  or  subcutaneous  necrotizing  nodules  associated  with  the  indolent  development  of  suppurating  nodules  along  the  course  of  the  proximal  lymphatics.  Extracutaneous  and  pulmonary  forms  of  the  disease  occur  infrequently.  The  histopathologic  findings  of  primary  cutaneous  disease  combine  features  of  both  granulomatous  and  pyogenic  inflammation.  Granulomatous  lesions  consist  of  aggregations  of  epithelioid  histiocytes  with  central  areas  of  necrosis  and  neutrophils  or  zones  of  Langhans  giant  cells  associated  with  fibroblasts  and  lymphocytes.  Occasionally,  areas  of  microabscesses  unassociated  with  granulomatous  reaction  may  be  seen.  In  chronic  disease,  pseudoepitheliomatous  hyperplasia  may  be  extensive  and  mimic  neoplasm.  A  common  histopathological  feature  is  the  asteroid  body,  a  round  basophilic,  yeastlike  structure  surrounded  by  rays  of  eosinophilic  material  thought  to  represent  antigen-antibody  complexes.  The  asteroid  body  may  also  be  seen  in  other  mycoses.