RT Book, Section
A1 Schleiss, Mark R.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7030068
T1 Chapter 312. Human Herpesviruses 6 and 7
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7030068
RD 2024/04/24
AB Human  herpesvirus  6  (HHV-6)  was  isolated  in  tissue  culture  in  1986  from  peripheral  blood  leukocytes  of  patients  with  both  lymphoproliferative  disorders  and  HIV  infection.  It  is  the  major  etiologic  agent  of  exanthem  subitum  and  has  also  been  implicated  in  other  clinical  syndromes.  HHV-6  is  a  prototypical  member  of  the  betaherpesvirus  family  of  herpesviruses,  which  also  includes  human  herpesvirus  7  (HHV-7)  and  human  cytomegalovirus  (HCMV).  The  virus  has  a  double-  stranded  DNA  genome  contained  within  an  icosahedral  capsid,  surrounded  by  an  outer  envelope.  HHV-6  is  subclassified  as  either  variant  A  or  B,  based  on  differences  in  nucleotide  sequence,  restriction  enzyme  profile,  and  reactivity  with  monoclonal  antibodies.  HHV-6B  is  the  subtype  associated  with  exanthem  subitum.1  In  contrast  to  the  other  human  herpesviruses,  which  are  maintained  in  a  latent  state  in  the  host  cell  as  circularized  genomes.