RT Book, Section
A1 Werlin, Steven L.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7038345
T1 Chapter 417. Disorders of the Exocrine Pancreas
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7038345
RD 2024/04/20
AB In  the  fourth  week  of  gestation,  the  human  pancreas  develops  as  two  outpouchings  of  the  duodenal  endoderm  (Figure  381-3  and  eFig.  417.1).1-3  The  larger  dorsal  bud  develops  into  the  tail,  body,  and  a  portion  of  the  head  of  the  pancreas.  The  ventral  bud  fuses  with  the  dorsal  bud  at  about  the  17th  week  of  gestation  to  create  the  remainder  of  the  head  of  the  pancreas  and  the  uncinate  process.  Each  bud  possesses  its  own  ductal  system;  variations  in  fusion,  which  occurs  in  15%  of  the  population,  lead  to  developmental  anomalies.  The  dorsal  duct  forms  the  distal  portion  of  the  duct  of  Wirsung  and  the  ventral  portion  forms  the  accessory  duct  of  Santorini,  which  empties  independently  in  about  15%  of  the  population.  Defective  fusion  of  the  two  pancreatic  primordia  leads  to  a  number  of  anatomic  anomalies  of  the  pancreatic  ductal  system  (see  also  Chapter  381).  Anomalies  in  this  developmental  process  can  have  clinical  implications.