RT Book, Section A1 Reiter, Edward O. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7052565 T1 Chapter 522. Growth and Growth Impairment T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7052565 RD 2024/04/25 AB Growth is a complex process that involves the interaction of multiple, diverse factors and represents the sum of these influences on cell replication and programmed cell death (apoptosis) and on cell differentiation. Growth is ultimately governed by the genome of a person and its interactions with external factors, such as nutrition and psychosocial well-being. Linear height growth may occur as a continuous process or with periodic bursts of growth and arrest.1-3During 1 year of growth monitoring, there may be marked seasonal variations of height and weight gain with several monthly bursts of weight and then height growth.4 Despite the complexity, healthy children usually grow linearly in a remarkably predictable manner. Change from a normal growth pattern often is the first manifestation of a disease, either an endocrine or a nonendocrine disorder that can involve almost any organ system. Frequent and accurate assessment of growth therefore is of primary importance in the care of children.