RT Book, Section
A1 Miller, Walter L.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7054114
T1 Chapter 535. Adrenal Excess
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7054114
RD 2024/04/23
AB Early  signs  of  glucocorticoid  excess  include  increased  appetite,  weight  gain,  and  growth  arrest  without  a  concomitant  delay  in  bone  age.  Chronic  glucocorticoid  excess  in  children  results  in  typical  Cushingoid  facies,  but  the  “buffalo  hump”  and  centripetal  distribution  of  body  fat  that  are  characteristic  of  adult  Cushing  disease  are  seen  only  in  long  standing  disease.  Mineralocorticoid  excess  is  characterized  by  hypertension,  but  patients  receiving  very  low  sodium  diets  (eg,  the  newborn)  will  not  be  hypertensive,  as  mineralocorticoids  increase  blood  pressure  primarily  by  retaining  sodium  and  thus  increasing  intravascular  volume.  Moderate  hypersecretion  of  adrenal  androgens  is  characterized  by  mild  signs  of  virilization;  substantial  hypersecretion  of  adrenal  androgens  is  characterized  by  accelerated  growth,  increased  bone  age,  increased  muscle  mass,  acne,  hirsutism,  and  deepening  of  the  voice.