RT Book, Section
A1 Khwaja, Omar
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7056522
T1 Chapter 549. Disturbances of the Neural Tube and Spine Closure
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7056522
RD 2024/04/19
AB Disorders  of  neural  tube  formation  and  closure  relate  to  disturbances  in  the  inductive  events  involved  in  primary  neurulation,  aberrant  closure  of  the  anterior  or  posterior  neuropore,  or  failure  of  the  caudal  regression  and  differentiation  events  that  lead  to  formation  of  the  lower  spinal  cord.  Correct  development  of  the  neural  tube  is  necessary  for  formation  of  the  dura  and  other  meninges,  cranium  and  vertebrae,  and  the  dermal  coverings.  Dysraphism  refers  to  persistent  continuity  between  the  posterior  neurectoderm  and  cutaneous  ectoderm.  External  manifestations  of  abnormal  cutaneous  ectoderm  may  be  the  only  initial  clinical  signs  of  occult  dysraphism.