RT Book, Section
A1 von Allmen, Daniel
A2 Ziegler, Moritz M.
A2 Azizkhan, Richard G.
A2 Allmen, Daniel von
A2 Weber, Thomas R.
SR Print(0)
ID 1100438872
T1 Neonatal Hypoglycemia
T2 Operative Pediatric Surgery, 2e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-162723-8
LK accesspediatrics.mhmedical.com/content.aspx?aid=1100438872
RD 2024/04/19
AB Hyperinsulinemic  hypoglycemia  is  the  common  cause  of  persistent  hypoglycemia  in  the  newborn.Mutations  in  the  ABCC8  and  KCNJ1  genes  are  most  common  and  impact  the  function  of  the  ATP  –  Potassium  Channel  in  the  Beta  cell  of  the  islet.Medical  therapy  includes  treatment  with  continuous  feedings,  diazoxide  and  somatostatin  analogs.The  2  primary  manifestations  of  the  disease  are  focal  and  diffuse.Patients  with  diffuse  disease  failing  medical  therapy  are  treated  with  95%  pancreatectomy.Patients  with  focal  disease  failing  medical  therapy  are  treated  with  complete  enucleation  of  the  lesion.Minimally  invasive  approaches  to  surgery  have  been  described.