RT Book, Section
A1 Gomella, Tricia Lacy
A1 Cunningham, M. Douglas
A1 Eyal, Fabien G.
A1 Tuttle, Deborah J.
SR Print(0)
ID 1107524985
T1 Rh Incompatibility
T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071768016
LK accesspediatrics.mhmedical.com/content.aspx?aid=1107524985
RD 2024/04/24
AB Isoimmune  hemolytic  anemia  of  variable  severity  may  result  when  Rh  incompatibility  develops  between  an  Rh-negative  mother  previously  sensitized  to  the  Rh  (D)  antigen  and  her  Rh-positive  fetus.  The  onset  of  clinical  disease  begins  in  utero  as  the  result  of  active  placental  transfer  of  maternal  immunoglobulin  (Ig)G-Rh  antibody.  It  is  manifested  as  a  partially  compensated,  moderate  to  severe  hemolytic  anemia  at  birth,  with  unconjugated  hyperbilirubinemia  developing  in  the  early  neonatal  period.