RT Book, Section
A1 Wong, Wendy
A1 Lo, Clara
A1 Glader, Bert
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109798691
T1 Thrombocytopenia
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109798691
RD 2024/04/19
AB Thrombocytopenia  in  neonates  is  defined  as  a  platelet  count  of  less  than  150  ×  109/L.  The  prevalence  of  thrombocytopenia  in  healthy  term  infants  is  1%–2%,  whereas  up  to  35%  of  neonates  admitted  to  intensive  care  units  may  have  low  platelet  counts.1  There  are  developmental  differences  in  megakaryopoiesis  between  neonates  and  older  children.  Neonatal  megakaryocytes  are  less  capable  of  upregulating  platelet  production  or  mounting  as  high  a  level  of  thrombopoietin  (Tpo)  when  compared  to  adults  with  the  same  degree  of  thrombocytopenia.2  These  developmental  differences  account  for  the  vulnerability  of  sick  neonates  to  thrombocytopenia.