RT Book, Section
A1 Lanpher, Brendan
A1 Summar, Marshall
A1 Batshaw, Mark L.
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109799248
T1 Neonatal Hyperammonemia
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109799248
RD 2024/04/23
AB Neonatal  hyperammonemia  is  a  feature  of  many  different  inborn  errors  of  metabolism  that  may  be  individually  rare  but  have  about  a  1:5000  cumulative  incidence.1,2  It  can  also  be  a  feature  of  fulminant  liver  failure  of  any  cause  and  of  structural  anomalies  leading  to  portosystemic  shunting.  Neonatal  hyperammonemia  represents  a  true  metabolic  emergency  as  rapid  identification  and  intervention  are  critical  to  a  positive  neurologic  outcome.  It  is  essential  that  neonatal  centers  have  a  protocol  and  plan  in  place  to  address  these  patients.  A  representative  protocol  is  provided  in  this  chapter  (Table  106-1)  and  details  are  provided.