The prognosis from ARF/AKI depends on the underlying cause or the extent of damage. If renal disease is caused by toxins or acute tubular necrosis, renal function may recover to some extent with time. Chronic renal failure may ensue as neonates with ARF/AKI are at increased risk. Mortality and morbidity are increased in newborns with multiorgan failure. Factors that increase mortality include hypotension, need for mechanical ventilation, dialysis, use of vasopressors, hemodynamic instability, and multiorgan failure. Follow-up with monitoring of urine, renal function, and blood pressure is necessary.