With early diagnosis and treatment, most infants will recover and not have any long-term problems. However, the mortality rate is still significant. For early-onset disease, the mortality rate is 5–10%, and for late-onset disease, the rate is 2–6%. For VLBW infants with early-onset disease, the fatality rate is higher (16% based on recent report from NICHD NRN). E. coli sepsis is associated with higher mortality compared with GBS.