Vomiting of bright red blood or active bleeding from the nasogastric (NG) tube is seen. Upper gastrointestinal (GI) bleeding is bleeding that occurs proximal to the ligament of Treitz in the distal duodenum (esophagus, stomach, or duodenum). The majority of GI bleeds in neonates are benign, self-limiting, and require minimal workup and treatment, but it is important to detect the cases that have significant underlying pathology.