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APPROACH TO PRIMARY IMMUNODEFICIENCY
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Warning Signs for Immune Deficiency. Consider immune deficiency when two or more of the following are present (data from Jeffrey Modell Foundation).
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Recurrent otitis (≥8 episodes), sinusitis (≥2 episodes), or pneumonia (≥2 episodes) in 1 year (from Jeffrey Modell Foundation)
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Two or more invasive infections (meningitis, sepsis, osteomyelitis, etc.)
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Recurrent deep skin or organ abscesses
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Infections with unusual or opportunistic organisms
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Failure to thrive
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Persistent thrush in mouth or elsewhere on skin after 1 year of age
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Need for intravenous antibiotics to clear common infections
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Family history of immunodeficiency
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The major categories of primary immune deficiencies reflect the various arms of the immune system (Tables 14-1 and 14-2).
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