Chromoblastomycosis The granulomatous process shown in Fig. 7-1, which is variegated in color, is of 12 years' duration. It started as a small nodule, developed slowly into a verrucous mass, and acquired satellite extensions. The condition, so reminiscent of a tuberculous process, is a deep fungal infection caused by the species of Phialophora, Fonsecaea, and Cladosporium, which are indigenous to parts of South America and other regions with warm climates. Lesions that are too large for surgical excision are treated with combinations of systemic flucytosine, amphotericin B, and ketoconazole.