Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android


Primary skin diseases that principally affect the epidermis may be categorized as either a dermatitis or a papulosquamous disorder. Dermatitis commonly denotes inflammation of the epidermis. Eczema generically denotes edema within the epidermis. Many primary dermatitides are eczematous in nature, although the term eczema is often misused interchangeably for atopic dermatitis (AD). In its mildest or chronic form, edema is seen histopathologically as prominent, tooth-like interconnections between keratinocytes (spongiosis). With more intracellular fluid accumulation, intraepidermal vesicles are formed. Vesicles are often subclinical in subacute or chronic eczemas where edema is mild but present as grossly evident vesicles and bullae in acute eczemas. Papulosquamous eruptions are characterized by the presence of erythematous papules or plaques with overlying scale. While eczematous processes clinically manifest with weeping or crusting, papulosquamous disorders are associated with little to no edema and thus clinically tend to be dry.


AD is the most common chronic inflammatory childhood skin disease, characterized by intense itching, dry skin, inflammation, and exudation. The typical clinical finding is an ill-defined patch or plaque of scaling and erythema. Pruritus is a constant feature. Chronic scratching results in dramatic accentuation of the skin markings (lichenification), sometimes with postinflammatory hyperpigmentation, whereas the chronic eczematous process itself may result in hypopigmentation.


The pathogenesis of AD is not completely understood. It is likely multifactorial, involving interplay between immune, genetic, metabolic, infectious, and environmental factors. Abnormalities of the epidermal barrier paired with immune dysregulation culminate in expression of this disease. A genetic basis for abnormal barrier function in some patients with AD has been linked to the FLG gene, the gene in which null mutations result in ichthyosis vulgaris, a scaly skin disorder in which 20% to 25% of people are also atopic. The FLG gene encodes filaggrin, a protein essential for epidermal barrier formation and hydration. Filaggrin is integral to the function of the lipid barrier in the epidermis, and mutations in filaggrin have been associated with severe or persistent AD.

While the exact prevalence of AD is unknown, a lifetime prevalence of 10% to 20% has been reported. The first US population-based study from the National Survey of Children’s Health reported a 10.7% prevalence in childhood AD with a wide variation between states from 8.7% to 18.1%. Symptoms begin during the first 6 months in 45% of children, first year of life in 60%, and before the age of 5 years in 90% of affected individuals.


In infancy, AD often affects the face, particularly the cheeks (Fig. 353-1), and the extensor surfaces of the extremities, but involvement of the scalp and trunk is also common. In older children, AD favors the flexures such as the antecubital and popliteal fossae. Ankles, wrists, and dorsa of hands and feet are also commonly involved. ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.