Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Key Features ++ Age: 6 months to 4 years Normocytic anemia with reticulocytopenia Absence of hepatosplenomegaly or lymphadenopathy Erythroid precursors initially absent from bone marrow +++ Clinical Findings ++ Pallor is the most common sign Hepatosplenomegaly and lymphadenopathy are absent +++ Diagnosis ++ Anemia is normocytic Peripheral blood smear shows no evidence of hemolysis Platelet count is normal or elevated Neutrophil count is normal or, in some cases, decreased Early in the course, no reticulocytes are identified The Coombs test is negative, and there is no evidence of chronic kidney disease, hypothyroidism, or other systemic disorder Bone marrow examination shows severe erythroid hypoplasia initially; subsequently, erythroid hyperplasia develops along with reticulocytosis, and the anemia resolves +++ Treatment ++ Some children require red cell transfusions if cardiovascular compromise is present Resolution of the anemia is heralded by an increase in the reticulocyte count, which generally occurs within 4–8 weeks of diagnosis Corticosteroids not needed because of short course Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth