Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Key Features ++ Characterized by diffuse or focal inflammation and edema of the renal interstitium and secondary involvement of the tubules Most commonly drug related (eg, β-lactam–containing antibiotics or nonsteroidal anti-inflammatory drugs), but infectious etiologies, including Epstein-Barr virus, also occur +++ Clinical Findings ++ Fever, rash, and eosinophilia may occur in drug-associated cases Association between tubulointerstitial nephritis and uveitis is occasionally seen in childhood +++ Diagnosis ++ Urinalysis usually reveals leukocyturia and mild hematuria and proteinuria Hansel staining of the urinary sediment often demonstrates eosinophils The inflammation can cause significant deterioration of renal function and systemic hypertension Renal biopsy may be performed to demonstrate the characteristic tubular and interstitial inflammation +++ Treatment ++ Immediate identification and removal of the causative agent whenever possible is imperative and may be all that is necessary Corticosteroids are helpful in patients with progressive kidney disease or associated nephrotic syndrome Dialysis support is occasionally required Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth