Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android

Key Features

  • Characterized by diffuse or focal inflammation and edema of the renal interstitium and secondary involvement of the tubules

  • Most commonly drug related (eg, β-lactam–containing antibiotics or nonsteroidal anti-inflammatory drugs), but infectious etiologies, including Epstein-Barr virus, also occur

Clinical Findings

  • Fever, rash, and eosinophilia may occur in drug-associated cases

  • Association between tubulointerstitial nephritis and uveitis is occasionally seen in childhood


  • Urinalysis usually reveals leukocyturia and mild hematuria and proteinuria

  • Hansel staining of the urinary sediment often demonstrates eosinophils

  • The inflammation can cause significant deterioration of renal function and systemic hypertension

  • Renal biopsy may be performed to demonstrate the characteristic tubular and interstitial inflammation


  • Immediate identification and removal of the causative agent whenever possible is imperative and may be all that is necessary

  • Corticosteroids are helpful in patients with progressive kidney disease or associated nephrotic syndrome

  • Dialysis support is occasionally required

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.