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Key Features

  • May complicate sepsis or dehydration in newborns

  • May be observed in infants of diabetic mothers

  • May be associated with umbilical vein catheterization

  • May result from any condition that produces a hypercoagulable state (eg, clotting factor deficiency, systemic lupus erythromatosus, or thrombocytosis)

  • Renal vein thrombosis is less common in older children and adolescents.

  • Spontaneous renal vein thrombosis has been associated with membranous nephropathy

Clinical Findings

  • In newborns, generally characterized by the sudden development of an abdominal mass

  • If bilateral, oliguria may be present

  • In older children, flank pain, sometimes with a palpable mass, is a common presentation

Diagnosis

  • No single laboratory test is diagnostic

  • Hematuria usually is present; may occasionally be gross in nature

  • Proteinuria is less constant

  • Thrombocytopenia may be found in newborn, but it is rare in older children

  • Ultrasonography and Doppler flow studies confirms diagnosis

Treatment

  • Anticoagulation with heparin is treatment of choice

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