Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Key Features ++ Incidence of trisomy 13 is about 1 per 12,000 live births, and 60% of affected individuals are female Risk of having a child affected with a trisomy increases with maternal age Most infants have congenital anomalies that are incompatible with survival Surviving children demonstrate failure to thrive, cognitive disabilities, apneic spells, seizures, and deafness Death usually occurs in early infancy or by the second year of life, commonly as a result of heart failure or infection +++ Clinical Findings ++ Characteristic features Normal birth weight Central nervous system malformations Eye malformations Cleft lip and palate Polydactyly or syndactyly Congenital heart disease +++ Diagnosis ++ Rapid confirmation of suspected trisomy 13 can be made by fluorescence in situ hybridization (FISH) +++ Treatment ++ General supportive care A support group for families is called SOFT (see http://www.trisomy.org/) Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.