Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Key Features ++ Incidence is about 1:4000 live births Ratio of affected males to females is approximately 1:3 Characterized by Prenatal and postnatal growth retardation, which is often severe Hypertonicity Complications are related to associated anomalies Death is often caused by heart failure or pneumonia and usually occurs in infancy or early childhood Small percentage reach adulthood; usually show significant cognitive disabilities A support group for families is called SOFT (see http://www.trisomy.org/) +++ Clinical Findings ++ Small for gestational age Dysmorphic features including a characteristic facies and extremities (overlapping fingers and rocker-bottom feet) Congenital heart disease (often ventricular septal defect or patent ductus arteriosus) +++ Diagnosis ++ Rapid confirmation of suspected trisomy 18 can be made by fluorescence in situ hybridization(FISH) +++ Treatment ++ Supportive Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth