Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Key Features ++ Webbed neck, triangular facies, short stature, wide-set nipples, amenorrhea, and absence of secondary sex characteristics Associated with coarctation of the aorta and genitourinary malformations IQ is usually normal but learning disabilities are common Mosaic individuals may manifest only short stature and amenorrhea Incidence is 1 per 10,000 females An estimated 95% of conceptuses with monosomy X are miscarried and only 5% are liveborn +++ Clinical Findings ++ Newborns may have webbed neck, edema of the hands and feet, coarctation of the aorta, and characteristic triangular facies Other findings in older girls may include Short stature Shield chest with wide-set nipples Streak ovaries Amenorrhea Absence of secondary sex characteristics Infertility Some affected girls, particularly those with mosaicism, have only short stature and amenorrhea, without dysmorphic features +++ Diagnosis ++ Prenatal ultrasonography and chromosome analysis are indicated for the offspring of females with sex chromosome abnormalities +++ Treatment ++ Academic supports for learning issues Hormonal treatment includes estrogen therapy, which permits development of secondary sex characteristics and normal menstruation, and prevents osteoporosis Growth hormone therapy is also used to increase the height of affected girls Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth