Skip to Main Content


  • Sepsis is a life-threatening condition that is characterized by an inflammatory response caused by an infection. Identifying and treating sepsis early is key to saving lives. Following are the sepsis definitions and treatment guidelines to help frame your approach to critically ill patients who have a suspected or confirmed diagnosis of sepsis.


  • An international pediatric sepsis consensus conference published a definition for pediatric systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock and organ dysfunction in 2005.1

  • Definitions in Table 29-1.1

  • Examples of organ dysfunction1:

    • Cardiovascular: Despite 40 cc/kg intravenous fluid given over 1 hour, patient has either hypotension, need for vasoactive infusion to maintain blood pressure, or evidence of decreased perfusion (ex: capillary refill >5 seconds, arterial lactate greater than two times normal)

    • Respiratory: Need for invasive or noninvasive positive pressure support, PaO2:FiO2 <300, requirement of >50% FiO2 to maintain saturations 92%, or PaCO2 >65 torr

    • Renal: Serum creatinine more than two times upper limit of normal for age or twofold increase in baseline creatinine

    • Hepatic: Total bilirubin 4 mg/dL (except newborns), ALT two times upper limit of normal

    • Neurologic: Glasgow Coma Score 11 or acute change in mental status

    • Hematologic: Platelet count <80,000/mm3 or 50% drop in platelet count from highest value in previous 3 days (for chronic hematology/oncology patients) or INR >2

TABLE 29-1

Definition of Sepsis


  • The host response to infection triggers both an inflammatory and compensatory anti-inflammatory response (CARS) mediated by the immune system. The balance between these two determines the extent of organ injury and patient recovery.

  • The innate immune response is nonspecific and triggered by the body's recognition of antigen resulting in an effector response. Components of the innate immune system include physical barriers like skin and phagycytic cells, such as macrophages, that recognize pathogens.

    • Pattern-recognition receptors (PRRs) are molecules in the host that recognize pathogen-associated ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.