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The Adolescence chapter includes information about patient-centered care strategies and use of motivational interviewing.

The Child Abuse & Neglect chapter includes the use of nucleic acid amplification tests to diagnose sexually transmitted diseases in pre-pubertal children evaluated for sexual abuse.

The Immunization chapter includes new discussions about how HPV vaccination can prevent cancer and how a newer HPV vaccine protects against additional HPV types. There also is new discussion about how most parents in the United States choose to vaccinate their children (in 2013, < 1% of young children received no vaccines) and the problems associated with parents' concerns about vaccines and the increasing number of parents who are choosing to delay or decline vaccination for their children.

The Poisoning chapter includes new recommendations for evaluation and treatment for common ingestions and exposures in the pediatric population, including pharmaceuticals, household products, and designer drugs.

The Skin chapter includes the use of propranolol for infantile hemangiomas.

The Eye chapter describes how instrument-based vision screening is a novel means of detecting vision-threatening amblyogenic risk factors in preverbal, preliterate, and developmentally delayed children, and is endorsed by the American Academy of Pediatrics.

The Oral Medicine & Dentistry chapter includes preventive dental treatment (fluoride varnish) by physicians for high-risk populations.

The Respiratory Tract & Mediastinum chapter introduces the new cystic fibrosis drug, Orkambi.

The Gastrointestinal Tract chapter identifies the life-threatening impact of button batteries as startling and significant health care problem.

The Liver & Pancreas chapter identifies two new oral therapies that are available for children with chronic hepatitis B: entecavir for children 3 years or older and tenofovir for children 12 years or older.

The Hematologic Disorders chapter notes that hydroxyurea therapy is now recommended for all children with sickle cell anemia or sickle β-thalassemia.

The Immunodeficiency chapter describes the use of genetic testing in the evaluation of children with immunodeficiency and states of immune dysregulation.

The Endocrine Disorders chapter includes the use of recombinant alkaline phosphatase (asfotase alfa) for the treatment of hypophosphatasia and how it has revolutionized therapy for this disorder.

The Inborn Errors of Metabolism chapter includes updated information about diagnostic testing for a variety of disorders.

The Genetics & Dysmorphology chapter includes information on microarray testing and whole exome sequencing.

The Viral and Rickettsial chapter includes the latest information about Zika virus and dengue.

The Antimicrobial Therapy chapter includes information on antimicrobial stewardship.

And many more!

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