AACN | American Association of Critical Care Nurses |
AAD | antibiotic-associated diarrhea |
AAO | American Academy of Otolaryngology |
AAP | American Academy of Pediatrics |
AAPOS | American Association for Pediatric Ophthalmology and Strabismus |
ABC | acute bacterial conjunctivitis |
ACE | angiotensin-converting enzyme |
ACIP | Advisory Committee on Immunization Practices |
ACOG | American College of Obstetrics and Gynecology |
ADEM | acute disseminated encephalomyelitis |
AD-HIES | autosomal dominant hyper-IgE syndrome |
ADP | adenosine diphosphate |
AER | Adverse Event Reporting |
AFB | acid-fast bacill(us)(i) |
AFM | acute flaccid myelitis |
Ag | antigen |
AGT | antiglobulin test |
AHA | American Heart Association |
AHO | acute hematogenous osteomyelitis |
AHRQ | Agency for Healthcare Research and Quality |
AIDS | acquired immunodeficiency syndrome |
AIIR | airborne infection isolation room |
ALL | acute lymphocytic leukemia |
ALN | acute lobar nephronia |
ALPS | autoimmune lymphoproliferative syndrome |
ALT | alanine aminotransferase |
AMPA | α-amino-3-hydroxy-5-methyl-4-isoxazolapropiomic acid |
ANA | antinuclear antibody |
ANC | absolute neutrophil count |
ANCA | antineutrophil cytoplasmic antibody |
AOE | acute otitis externa |
AOM | acute otitis media |
APECED | autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (dysplasia) |
APIC | Association for Professionals in Infection Control |
APSAC | American Professional Society of the Abuse of Children |
ARF | acute rheumatic fever |
ARR | absolute risk reduction |
ART | antiretroviral therapy |
ASM | American Society for Microbiology |
ASO | antistreptolysin O |
AST | aspartate aminotransferase |
AT | ataxia telangiectasia |
ATM | acute transverse myelitis |
ATS | American Thoracic Society |
ATV | atazanavir |
AUC | area under the (time–concentration t/C) curve |
AUC/MIC | area under the (t/C) curve over the minimum inhibitory concentration (Ch 8; ratio of total drug exposure over time, represented as an area under the t/C curve, over MIC) |
AUROC | area under receiver–operator characteristic curve |
AVM | malformation |
AWARE | Assessing Worldwide Antimicrobial Resistance Evaluation |
AZT | zidovudine |
BAL | bronchoalveolar lavage |
BBB | blood–brain barrier |
BCG | bacille Calmette–Guérin |
BCPPS | Board Certified Pediatric Pharmacy Specialist |
BCSA | Burkholderia cepacia–selective agar |
BCYE | buffered charcoal–yeast extract |
BGMK | buffalo green monkey kidney |
BJI | bone–joint infection |
BMI | body mass index |
BNP | B-type natriuretic peptide |
BRAT | bananas, rice, applesauce, toast |
BRUE | brief, resolved, unexplained event |
BSA | body surface area |
BSEP | bile salt export pump |
BSI | bloodstream infection |
BSL | biosafety level |
BTX | botulinum toxin |
BUN | blood urea nitrogen |
CA | community-acquired |
CAA | coronary artery aneurysm |
CAP | community-acquired pneumonia |
CAPS | cryopyrin-associated periodic syndrome |
CART | combination antiretroviral therapy |
CBC | complete blood count |
CBDI | Cancer and Blood Disease Institute |
CDC | Centers for Disease Control and Prevention |
CD4 | cluster of differentiation 4 |
CDI | Clostridium difficile infection |
CDR | Candida drug resistance |
CE | Conformité Européenne |
CERN | Chicago Ebola Response Network |
CF | cystic fibrosis |
CFU | colony-forming unit |
CGD | chronic granulomatous disease |
CHD | congenital heart disease |
CHG | chlorhexidine gluconate |
CHIME | Collaborative Home Infant
Monitoring Evaluation |
CI | confidence interval |
CIA | chemiluminescence immunoassay |
CIAIS | cold-induced autoinflammatory syndrome |
CIC | Certified Inpatient Coder |
CINCA | chronic infantile neurologic cutaneous–articular (syndrome) |
CLABSI | central line–associated bloodstream infection |
CLIA | Clinical Laboratory Improvement Amendments |
CLSI | Clinical and Laboratory Standards Institute |
CMP | chemistry panel |
CMR | cardiovascular magnetic resonance |
CMV | cytomegalovirus |
CNS | central nervous system |
CoNS | coagulase-negative Staphylococcus |
CoV | coronavirus |
CPAM | congenital pulmonary airway malformation |
CPE | cytopathic effect |
CPIC | Clinical Pharmacogenetics Implementation
Consortium |
CPK | creatine phosphokinase |
CPS | Canadian Paediatric Society |
CRBSI | catheter-related bloodstream infection |
CRE | carbapenem-resistant enterobacteriaceae |
CRF | circulating recombinant form |
CRMO | chronic recurrent multifocal osteomyelitis |
CRMP | collapsing-responsive mediator protein |
CRP | C-reactive protein |
CRS | congenital rubella syndrome |
CSF | cerebrospinal fluid |
CST | cavernous sinus thrombosis |
CT | computed tomography |
CTBA | cystine tellurite blood agar |
CVC | central venous catheter |
CVID | common variable immunodeficiency |
CXR | chest X-ray |
CZS | congenital Zika syndrome |
DAMP | damage-associated molecular pattern |
DAT | direct antiglobulin test |
DBS | deep-brain stimulation |
DCI | data collection instrument |
DCM | dilated cardiomyopathy |
DCT | direct Coombs test |
DEET | N,N-diethyl-meta-toluamide (also known as diethyltoluamide) |
DES | dysfunctional elimination syndrome |
DEXA | dual-energy X-ray absorptiometry |
DFA | direct fluorescent antibody |
DGI | disseminated gonococcal infection |
DHHS | Department of Health and Human Services |
DIC | disseminated intravascular coagulation |
DIH | drug-induced hypersensitivity |
DIRA | deficiency of IL (interleukin)-1 receptor agonist |
DNA | deoxyribonucleic acid |
DOCK8 | dedicator of cytokinesis 8 gene |
DOT | directly observed therapy |
DRESS | drug reaction with eosinophilia and systemic
symptoms |
DRV | darunavir |
ds | double strength (in prescriptions) |
DSM | Diagnostic and Statistical Manual |
DTaP | diphtheria–tetanus–acellular
pertussis (vaccine) |
DTG | dolutegravir |
d-TGA | dextro-transposition of the great arteries |
DWI | diffusion-weighted imaging |
EAC | external auditory canal |
EACTS | European Association of
Cardio-Thoracic Surgery |
EANM | European Association of Nuclear Medicine |
EBNA | Epstein–Barr nuclear antigen |
EBUS-NA | endobronchial ultrasound-guided
needle aspiration |
EBV | Epstein–Barr virus |
ED | emergency department |
EDTA | ethylenediamine tetra (acetic acid) |
EEE | eastern equine encephalitis |
EES | erythromycin ethylsuccinate |
EFV | efavirenz |
EGA | estimated gestational age |
EHEC | enterohemorrhagic Escherichia coli |
EIA | enzyme immunoassay |
ELF | epithelial lung fluid |
ELISA | enzyme-linked immunosorbent assay |
EKG | electrocardiogram |
EMLA | eutectic mixture of local anesthetics |
EMR | electronic medical record |
EMTCT | elimination of mother-to-child
transmission (of HIV) |
EPA | Environmental Protection Agency (US) |
ERCP | endoscopic retrograde
cholangiopancreatography |
ESBL | extended-spectrum β-lactamase |
ESC | European Society of Cardiology |
ESCMID | European Society of Clinical Microbiology and Infectious Diseases |
ESPGHAN | European Society of Pediatric Gastroenterology, Hepatology, and Nutrition |
ESR | erythrocyte sedimentation rate |
ESRD | end-stage renal disease |
ETEC | enterotoxigenic Escherichia coli |
ETV | etravirine |
EUCAST | European Committee on Antimicrobial Susceptibility Testing |
EV | enterovirus |
EVD | external ventricular drain |
FAUC/MIC | ratio of free (non-protein-bound) drug exposure over time, represented as area under the time–concentration (t/C) curve, over the minimum inhibitory concentration |
FCAS | familial cold autoinflammatory syndrome |
FCU | familial cold urticaria |
FDA | Food and Drug Administration (US) |
FESS | functional endoscopic sinus surgery |
FI | fusion inhibitor |
F&I | febrile and immunocompromised |
FIRS | fetal inflammatory response syndrome |
5-FC | 5-fluorocytosine |
5-FU | 5-fluorouracil |
FLAIR | fluid-attenuated inversion recovery |
FMEA | failure modes and effects analysis |
FMF | familial Mediterranean fever |
FMT | fecal microbiota transplantation |
FNA | fine-needle aspiration |
FNAB | fine-needle aspiration biopsy |
FP, FN | false positive, false negative |
FTA-abs | fluorescent treponemal antibody absorption |
FTC | emtricitabine |
FTT | failure to thrive |
FUO | fever of unknown origin |
FWS | fever without a source |
GABA | γ-aminobutyric acid |
GABHS | group A β-hemolytic Streptococcus |
GAS | group A Streptococcus |
GBS | group B Streptococcus |
GCSF | granulocyte colony-stimulating factor |
GCV | ganciclovir |
GDH | glutamate dehydrogenase |
GEE | generalized estimating equation |
GERD | gastroesophageal reflux disease |
GFR | glomerular filtration rate |
GGT | γ-glutamyltransferase |
GHD | graft-versus-host disease |
GI | gastrointestinal |
Glut1 | glucose transporter type 1 |
G6PD | glucose-6-phosphate dehydrogenase |
GU | genitourinary |
GWAS | genome-wide association study |
HAART | highly active antiretroviral therapy |
HACEK | Haemophilus, Actinobacillus (now Aggregatibacter), Cardiobacterium, Eikenella, Kingella (genera) |
HAI | healthcare-associated infection |
HAV | hepatitis A virus |
HBcAg | hepatitis B core antigen |
HBeAg | hepatitis B e-antigen |
HBIG | hepatitis B immunoglobulin |
HBsAg | hepatitis B surface antigen |
HCV | hepatitis C virus |
HCW | healthcare worker |
HDAF | human decay–accelerating factor |
HDV | hepatitis D virus |
HEPA | high-efficiency particulate air |
HEV | hepatitis E virus |
HIDS | hyper-IgD (with periodic fever) syndrome |
HFNC | high-flow nasal cannula |
HHV | human herpesvirus |
Hib | Haemophilus influenzae type b |
HICPAC | Healthcare Infection Control Practices Advisory Committee |
HIV | human immunodeficiency virus |
HLA | human leukocyte antigen |
HLH | hemophagocytic lymphohistiocytosis |
hMPV | human metapneumovirus |
HNS | head and neck surgery |
HPF | high-power field |
HPLC | high-performance liquid chromatography |
HPV | human papillomavirus |
HRV | human rhinovirus |
HSCT | hematopoietic stem cell transplant |
HSP | Henoch–Schönlein purpura |
HSV | herpes simplex virus |
HTLV | human T-cell lymphotropic virus |
HUS | hemolytic–uremic syndrome |
hVISA | heterogeneous vancomycin intermediate Staphylococcus aureus |
IAP | intrapartum antibiotic prophylaxis |
IAT | indirect antiglobulin test |
IBD | inflammatory bowel disease |
IBI | invasive bacterial infection |
ICP | intracranial pressure |
ICU | intensive care unit |
IDSA | Infectious Diseases Society of America |
IDU | injection drug use(r) |
IE | infective endocarditis |
IFI | invasive fungal infection |
Ig | immunoglobulin (IgA, IgG, IgM, etc) |
IGRA | interferon-γ release assay |
IHI | Institute for Healthcare Improvement |
IM | intramuscular(ly) |
INR | International Normalized Ratio |
IPC | infection prevention and control |
IPD | invasive pneumococcal disease |
IPEX | immune dysregulation, polyendocrinopathy, enteropathy, X-linked |
iPrEx | preexposure prophylaxis initiative (trial; initiativa profilaxis pre-exposicion) |
IPV | inactivated polio vaccine |
IQ | intelligence quotient |
IQR | interquartile range |
IRF | interferon regulatory factor |
IRIS | immune reconstitution inflammatory syndrome |
ISC | International Society of Chemotherapy |
I/T | immature-to-total ratio (sepsis ratio) |
ITB | intrathecal baclofen |
IU | international unit |
IUD | intrauterine device |
IV | intravenous |
IVIG | intravenous immunoglobulin |
JCV | John Cunningham virus |
JDMS | juvenile dermatomyositis |
JEV | Japanese encephalitis virus |
JIA | juvenile idiopathic arthritis |
KD | Kawasaki disease |
KID | Kids’ Inpatient Database |
KOH | potassium hydroxide |
LAD | leukocyte adhesion deficiency |
LAIV | live-attenuated intranasal influenza vaccine |
LAM | lipoarabinomannan |
LCA | left coronary artery |
LCH | Langerhans cell histiocytosis |
LCMV | lymphocytic choriomeningitis virus |
LCV | LaCrosse virus |
LDH | lactate dehydrogenase |
LF | lateral flow |
LFT | liver function test |
LGBT | lesbian, gay, bisexual, transgender |
LGl | leucine-rich glioma |
LGli1 | leucine-rich glioma inactivated 1 |
LIP | lymphoid interstitial pneumonia |
LLQ | left lower quadrant |
LN | lymph node |
LoR | level of reliability |
LOS | length of stay (in hospital) |
LP | lumbar puncture |
LPS | lipopolysaccharide |
LPV/r | lopinavir/ritonavir |
LR | likelihood ratio |
LTBI | latent tuberculosis infection |
LUQ | left upper quadrant |
LV | left ventricular |
MA | mevalonic aciduria |
MAC | Mycobacterium avium complex |
MAI | Mycobacterium avium intracellulare |
MALDI-TOF | matrix-assisted laser desorption and ionization time-of-flight (mass spectrometry) |
MAT | microscopic agglutination test |
MBC | minimum bactericidal concentration |
MDR | multidrug resistance |
MDRO | multidrug-resistant organism |
MEE | middle-ear effusion |
MERS | Middle East respiratory syndrome |
MFI | multiflex flow immunoassay |
MGIT | mycobacteria growth indicator tube |
MIBG | metaiodobenzylguanidine |
MIC | minimum inhibitory concentration |
MLM | multilevel model |
MLS | macrolide–lincosamide–streptogramin |
MMR | measles–mumps–rubella |
MRI | magnetic resonance imaging |
MRSA | methicillin-resistant Staphylococcus aureus |
MSBP | Munchausen syndrome by proxy |
MSG | Mycosis Study Group |
MSM | men who have sex with men |
MSSA | methicillin-susceptible Staphylococcus aureus |
Mtb | Mycobacterium tuberculosis |
N/A | not applicable or (data) not available (used in tables only) |
NAAT | nucleic acid amplification test |
NADPH | nicotinamide adenine dinucleotide phosphate |
NASPGHAN | North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition |
NBTE | nonbacterial thrombotic endocarditis |
NCNGU | nonchlamydia, nongonococcal urethritis |
NEMO | NF-κB-essential modulator |
NF | nuclear factor |
NFAT | nuclear factor of activated T cells |
NHANES | National Health and Examination Survey |
NHSN | National Healthcare Safety Network |
NI | neurologic impairment |
NICE | National Institute (for Health and) Clinical Excellence (UK) |
NICU | neonatal (or newborn) intensive care unit |
NMDA-R | N-methyl-d-aspartate receptor |
NMO | neuromyelitis optica |
NNRTI | nonnucleoside reverse transcriptase inhibitor |
NNT | number needed to treat |
NOMID | neonatal-onset multisystem inflammatory disease |
NP | nasopharyngeal |
NPA | nasopharyngeal aspirate |
nPEP | nonoccupational postexposure prophylaxis |
NPS | nasopharyngeal swab |
NPUAP | National Pressure Ulcer Advisory Panel |
NPV | negative predictive value |
NPW | nasopharyngeal wash |
NRTI | nucleoside reverse transcriptase inhibitor |
NSAID | nonsteroidal anti-inflammatory drug |
NTM | nontuberculous mycobacteria |
NT-proBNP | N-terminal pro-B-type natriuretic peptide |
NVP | nevirapine |
ODT | orally disintegrating tablet |
OE | otitis externa |
OFPBL | oxidation–fermentation with polymyxin B, bacitracin, and lactose |
OI | opportunistic infection |
OM | otitis media |
OMAS | opsoclonus–myoclonus–ataxia syndrome |
O&P | ova and parasite |
oPEP | occupational postexposure prophylaxis |
OR | odds ratio |
ORS | oral rehydration solution |
ORT | oral radiation therapy |
OSHA | Occupational Safety and Health Administration |
OTC | over the counter |
PA | posterior–anterior (also posteroanterior) |
PAE | postantibiotic effect (amount of time that bacterial regrowth is suppressed following removal of an antibiotic) |
PaLoc | pathogenicity locus in Clostridium difficile |
PAMP | pathogen-associated molecular pattern |
PAN | polyarteritis nodosa |
PANDAS | pediatric autoimmune neuropsychiatric disorder(s) associated with streptococcal infection |
PANS | pediatric acute-onset neuropsychiatric syndrome |
PaO2 | partial pressure of arterial oxygen |
PAPA | pyogenic sterile arthritis; pyoderma gangrenosum and acne |
PAPR | powered air-purified respirator |
PAS | periodic acid–Schiff (stain) |
PASOJAR | Pennsylvania Systemic Onset Juvenile Arthritis Registry |
PBP | penicillin-binding protein |
PCD | primary ciliary dyskinesia |
PCF | pediatric condition falsification |
PCN | penicillin |
PCO2 | partial pressure of carbon dioxide |
PCP | Pneumocystis jiroveci pneumonia |
PCR | polymerase chain reaction |
PCT | procalcitonin |
PCV | pneumococcal (protein–polysaccharide) conjugate vaccine |
PCV13 | 13-valent pneumococcal conjugate vaccine |
PD | pharmacodynamic |
PDC | potential diagnostic clue |
PDSA | plan–do–study–act |
PEACH | pelvic inflammatory disease (PID) Evaluation and Clinical Health Study |
PedsQL | Pediatric Quality of Life |
PEMCRC | Pediatric Emergency Medicine Collaborative Research Committee |
PFAPA | periodic fever–adenitis–pharyngitis–aphthous ulcer |
PfEMP1 | Plasmodium falciparum erythrocyte membrane protein 1 |
PGM3 | phosphoglucomutase 3 gene |
PHIL | Public Health Image Library |
PHMB | poly(hexamethyl biguanide) |
PI | protease inhibitor |
PICC | peripherally inserted central
venous catheter |
PICNIC | Pediatric Investigators Collaborative Network on Infections in Canada |
PICU | pediatric intensive care unit |
PID | pelvic inflammatory disease |
PIDS | Pediatric Infectious Diseases Society |
PK | pharmacokinetic |
PLEX | plasma exchange |
PLoS | Public Library of Science |
PML | progressive multifocal leukoencephalopathy |
PMN | polymorphonuclear neutrophil |
PO | per os (orally; by mouth) |
PPD | purified protein derivative |
PPE | personal protective equipment |
PPSV23 | 23-valent pneumococcal polysaccharide vaccine |
PPV | positive predictive value |
PrEP | preexposure prophylaxis |
PRES | posterior reversible encephalopathy syndrome |
PRIVENT | Prevention of Recurrent (urinary tract) Infection (in children with) Vesicoureteric (reflux) Normal (renal) Tract (mnemonic) |
PROS | Pediatric Research Office Settings |
PRP | poly(ribosylribitol phosphate) |
PSRA | poststreptococcal reactive arthritis |
PT | physical therapy |
PTA | peritonsillar abscess |
PVA | polyvinyl alcohol |
PVL | periventricular leukomalacia |
PZA | pyrazinamide |
Q/D | quinupristin/dalfopristin |
QI | quality improvement |
RAD | reactive-airway disease |
RADT | rapid antigen detection test |
RAISE | Randomized controlled trial to Assess Immunoglobulin plus Steroid Efficiency |
RAL | raltegravir |
RBC | red blood cell |
RBUS | renal bladder ultrasound |
rCDI | recurrent Clostridium difficile infection |
RCT | randomized controlled trial |
REM | rapid eye movement |
RIA | radioimmunoassay |
RIG | rabies immunoglobulin |
RIVUR | Randomized Intervention (for children with) Vesicourethral Reflux |
RLQ | right lower quadrant |
RMSF | Rocky Mountain spotted fever |
RN | registered nurse |
RNA | ribonucleic acid |
RODEO | ROutine versus on DEmand removal Of the syndesmotic stabilization screw (trial) |
RPA | retropharyngeal abscess |
RPR | rapid plasma regain |
RR | relative risk |
RRR | relative risk reduction |
RSV | respiratory syncytial virus |
RT | real time |
RUQ | right upper quadrant |
RV | right ventricle |
SARS | severe acute respiratory syndrome |
SBECD | sulfobutylether-β-cydodextrin |
SBI | serious bacterial infection |
SCC | staphylococcal chromosome cassette |
SCID | severe combined immunodeficiency |
SCIWORA | spinal cord injury without radiographic abnormality |
Scr | serum creatinine |
SD | standard deviation |
SDD | susceptible-dose-dependent |
SDF | silver diamine fluoride |
SEM | skin, eye, and mucous (also mouth) membranes |
SES | socioeconomic status |
SHEA | Society for Healthcare Epidemiology of America |
SIADH | syndrome of inappropriate antidiuretic hormone (secretion) |
SIDS | sudden infant death syndrome |
SIM | simian immunodeficiency virus |
SJIA | systemic juvenile idiopathic arthritis |
SJS | Stevens–Johnson syndrome |
SMART | specific, measurable, achievable, relevant, time-bound (mnemonic) |
SNHL | sensorineural hearing loss |
SPAG | small-particle aerosol generator |
SPECT | single-photon emission computed tomography |
SPG | sphenopalatine ganglion |
SPIDS | Saudi Pediatric Infectious Diseases Society |
SPS | sodium polyanetholsulfonate |
SSI | surgical site infection |
SSPE | subacute sclerosing panencephalitis |
SSSS | staphylococcal scalded-skin syndrome |
SSTI | skin and soft tissue infection |
STAT3 | signal transducer and activator of transcription
3 gene |
STD | sexually transmitted disease |
STEC | Shiga toxin–producing Escherichia coli |
TB | tuberculosis |
TBE | tickborne encephalitis |
TCBS | thiosulfate citrate bile sucrose |
Tdap | tetanus–diphtheria–acellular pertussis |
TDF-FTC | tenofovir–emtricitabine |
TDSA | thymidine-dependent Staphylococcus aureus |
TEE | transesophageal echocardiography |
TIG | tetanus immunoglobulin |
TIV | trivalent inactivated influenza vaccine |
TM | tympanic membrane |
TMP-SMX | trimethoprim–sulfamethoxazole |
TNFα | tumor necrosis factor alpha |
TOA | tubo-ovarian abscess |
TORCH | Toxoplasma gondii, Other microorganisms, Rubella, Cytomegalovirus, Herpes simplex virus (mnemonic) |
TP, TN | true positive, true negative |
TPPA | Treponema pallidum particle agglutination |
TRAPS | tumor necrosis factor (TNF)–receptor–associated periodic syndrome |
TRUST | Tracking Resistance in US Today (mnemonic) |
TSS | toxic shock syndrome |
TST | tuberculin skin test |
TTE | transthoracic echocardiography |
TUBC | transurethral bladder catheterization |
UA | urinalysis |
UGI | upper gastrointestinal (barium series) |
URI | upper respiratory infection |
USPHSTF | US Public Health Service Task Force |
UV | ultraviolet |
VAC | ventilator-associated condition |
VAERS | Vaccine Adverse Event Reporting System |
VATS | video-assisted therascopic surgery |
VCA | viral capsid antigen |
VCUG | voiding cystourethrogram |
Vd | volume of distribution |
VDRL | venereal disease research laboratory |
VFR | visiting friends and relatives |
VP | ventriculoperitoneal |
V/Q | ventilation/perfusion |
VRE | vancomycin-resistant enterococcus |
VSD | Vaccine Safety Datalink |
VUR | vesicourethral reflux |
VZV | varicella zoster virus |
WASP | wait-and-see prescription |
WBC | white blood cell |
WHIM | warts, hypogammaglobulinemia, infections, and myelokathexis |
WHO | World Health Organization |
WNV | West Nile virus |
XLA | X-linked agammaglovulinemia |
XLP | X-linked lymphoproliferative (disease) |
YMSM | young men who have sex with men |
ZDV | zidovudine |