General | Malaise, fever, adenopathy | Lymphoma, leukemia, EWS, NBL |
Hypertension | Renal or adrenal tumors, NBL |
Weight loss | Any malignancy |
Growth failure | Pituitary tumors |
Electrolyte disturbances | Hypothalamic tumors |
HEENT | Earache | STS |
White spot on eye in photograph | Retinoblastoma |
Orbital ecchymoses | NBL, LCH, RMS (Rhabdomyosarcoma) |
Rhinitis | STS |
Epistaxis | Leukemia |
Pharyngitis | STS |
Adenopathy | NBL, thyroid, STS, lymphoma, leukemia |
Thorax |
Extrathoracic | Soft tissue mass | STS, PNET (primitive neuroectodermal tumor) |
Bony mass | EWS, NBL |
Intrathoracic | Adenopathy | Lymphoma, leukemia |
Abdomen | External: Soft tissue | STS, PNET |
Internal: Diarrhea, vomiting, HSM | NBL, lymphoma, hepatic tumor, leukemia, WT |
Urinary | Hematuria | WT, STS |
Trouble voiding | Prostatic or bladder STS |
Genital | Vaginitis | STS |
Scrotal mass | STS, lymphoma, leukemia, germ cell tumor, yolk sac tumor |
Musculoskeletal | Soft tissue mass | RMS, other STS, PNET, germ cell tumor |
Bony mass or pain | Osteosarcoma, EWS, NHL, NBL, leukemia, LCH |
Neurologic | Headache, vomiting | Brain tumor, leukemia |
Cranial nerve palsy, ataxia | Brain tumor, leukemia, NBL |
Signs of spinal cord compression | NBL, brain tumor, spinal cord tumor, LCH, leukemia, lymphoma |
Skin | Petechiae | Leukemia, NBL |