Where skin is in natural apposition (for example, in the axillae, intergluteal folds, and neck folds) or where the skin is occluded, it is susceptible to the effects of wetness, higher temperature, friction, and accumulated debris. An area of slight erythema in the neck fold is illustrated here. The skin is superficially inflamed from excessive maceration of the stratum corneum, caused by retention of wetness from washing and insufficient drying or from retained sweat. Group A B-hemolytic strep and Candida albicans infections need to be considered.