Conradi's disease, or chondrodysplasia punctata, is actually a group of related syndromes that have differing prognoses and modes of inheritance. Skin changes are seen in some of the patients with each of the disease subtypes. The newborn may present as a collodion baby (see Fig. 12-19). In early infancy, there develops a generalized, whorled ichthyosiform erythroderma, as illustrated in these two figures. Over time, the areas of ichthyosis are replaced by blotchy hyperpigmentation and then, sometimes, by follicular atrophoderma. Patchy alopecia may also occur. Systemic features of chondrodysplasia punctata include stippling of the epiphyses, shortening of the femur and humerus, congenital cataracts, and saddle nose. The autosomal recessive form, also termed rhizomelic dwarfism, is most severe and usually causes psychomotor retardation and seizures. Those patients with the autosomal dominant disease (Conradi-Hünermann syndrome) have a generally better prognosis.