The infant pictured here has a severe generalized erythroderma with diffuse scaling. In the past, the term “Leiner's disease” was used to describe children with severe and widespread seborrheic dermatitis-like eruptions, diarrhea, failure to thrive, and recurrent infections. The clinical presentation, which includes erythroderma, diarrhea, and growth failure, may result from a variety of immunologic abnormalities, including Netherton's syndrome (Fig. 12-27, 12-28, 12-29, 12-30). A complete workup is mandatory in patients with this constellation of symptoms.