This genetic disorder is transmitted as an autosomal dominant, with variable penetrance. It is characterized grossly by partial albinism in the form of a white forelock (Fig. 24-7), broad nasal root (Figs. 24-7 and 24-8), hypertrichosis of the inner portions of the eyebrows, lateral displacement of the medial canthi (Figs. 24-7 and 24-8), partial or complete heterochromia of the irides (Fig. 24-7), and complete or unilateral deafness. In African Americans, blue irides, vitiligo, and pigmentary changes in the fundi may be seen. There are no other constitutional symptoms, but the hearing loss and unusual appearance may pose handicaps.